alexa Abstract | Class II drugs; a dissolution / bioavailability challenge: Flutamide-loaded spray dried lactose for dissolution control

International Journal of Drug Development and Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)


Flutamide (FL) is the only presently recommended drug for monotherapy of benign prostatic hypertrophy. Five FL-loaded powdered formulations were prepared by spray drying. Aerosil was used with PEG 400 or PEG 6000 to improve powder flow and FL dissolution, respectively. Differential Scanning Calorimetry (DSC) studies revealed no interactions as evidenced by the persisting FL peak at 113oC. SEM pictures showed changes in powder morphology with F3 and F5 giving spongy-appearing particles with intra-particle channels. Wettability of the formulations was strongly increased as evidenced by the fast water rise through the powder bed (1.5- 44 min) compared with native FL (> 3 hr). The powders were tested for their angle of repose, Carr’s index and Hausner’s ratio. The results showed improved flow compared to both native FL and lactose. The best angle of repose (27.4o ) was seen with F3. This formulation also showed "fair" compressibility index and Hausner's ratio of 16.7 and 12.0, respectively. Compressed into tablets, all formulations showed significant improvement of FL release (p < 0.05)compared to commercial tablets. The highest drug release was seen with F3 showing 37% of FL released after 120 minutes compared with 11% FL released from commercial tablet after the same interval.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Wael M Samy


Flutamide, DSC, powder wettability, angle of repose, Carr’s index, Hausner’s ratio

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version