alexa Abstract | Clinical, Hematological and Histopathological Responses to Arsenic Toxicity in ICR Mice Using Arsenic Levels Synonymous to Buruli Ulcer Endemic Communities in the Amansie West District of Ghana

European Journal of Experimental Biology
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


Arsenic poisoning has become one of the major environmental concerns in the world as millions of people have been exposed to excessive arsenic through contaminated drinking water. In this study, ICR mice were introduced to 0.8 -4.8 mgL-1 arsenic, synonymous to arsenic detected from streams and soils in Buruli Ulcer endemic communities of the Amansie West District of the Ashanti Region of Ghana, via their drinking water. Mice with arsenic exposure of 4.0-4.8 mgL-1 developed inflammation, erythema and open ulcers on skin (with scab formation). The scabs upon examination were negative for acid fast bacilli. Histopathological studies revealed liver and spleen damage. There was hepatic cell swelling with the loosening of cell wall and degenerative change with cells showing cytoplasmic vacoulation with nuclear blebbing and gradual cell loss. The spleen developed a lymphoid background with multinucleate cells formation. Hematological examination revealed significant dose-dependent decrements in white blood cells indicating a detrimental effect on the body’s immune system, a situation which makes the body susceptible to infections including M. ulcerans. The mean corpuscular volume of red blood cells also decreased significantly indicating microcytosis. High levels of arsenic in tissue (possibly from accumulation) cause inflammation, erythema and open ulcers on the skin, and has the potential to cause liver and spleen damage, reduced immune system function, and red blood cell microcytosis in ICR mice.

Author(s): Samuel Fosu Gyasi Esi Awuah John A Larbi George Asumeng Koffuor and OwusuAfriyie Osei


Arsenic trichloride, Buruli Ulcer, Microcytosis, Erythema, Inflammation

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version