alexa Abstract | CNS STIMULATION EFFECT OF SEMISYNTHETIC ADDUCT OF CAFFEINE WITH SCHIFFÂ’S BASE OF PYRAZOLONE AND PYRAZOLO-PYRIMIDINE NUCLEUS

International Journal of Drug Development and Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

The CNS stimulation study has been performed on the two semisynthetic adducts of caffeine with Schiff?s base of pyrazolone and pyrazolone-pyrimidine nucleus. All the reference drugs and test compounds showed positive effect on CNS stimulation. The conclusion has been drawn from the fact that CNS stimulation effect for pentylene tetrazole is higher than caffeine, compound-I (pyrazolone ring) is less active than compound-II as the compound-II (pyrazolo-pyrimidine ring) is fused ring heterocyclic compound and the synergistic action with caffeine with compound-I having less activity than the compound-II but in case of leptazol (pentylene tetrazole), the synergistic activity of the two test compounds are equal but less than leptazol itself. The azole group is present in both caffeine and in leptazol but in fused ring heterocyclic chromophore and the same ring has been implemented in the two test compounds which have been semisynthesized by formation of Schiff?s base of caffeine to keep the similar bioisosteric nature. So, the components that have been semisynthesized showed the specific CNS stimulation activity.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): DIPESHKUMAR A CHAUDHARI AND DHRUBO JYOTI SEN

Keywords

Pyrazolone, pyrazolone-pyrimidine, caffeine, leptazol, CNS stimulation

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us