alexa Abstract | Cognitive function in patients with Type 2 Diabetes Mellitus: Relationship to stress hormone(Cortisol)

Journal of Neurology and Neuroscience
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


Chronic hyperglycemia and hypercortisolemia have deleterious effect on the hippocampus, brain area responsible for learning and memory. We aimed to determine the relationship between hypercorticolemia and cognitive function with T2DM. Included were 57 patients. Cognition was tested using battery of psychometric testing (Mini-Mental State Examination or MMSE, Stanford Binet Test (4th edition) or SBST and Wechsler Memory Scale-Revised or WMS-R) and by recording P300 component of Event Related Potential (ERPs). Depression was assessed using Beck Depression Inventory (BDI-II). We also measured cortisol at basal state and after dexamethasone injection. Compared to controls (n=40), patients had lower scores of subsets and total scores of cognitive testing (MMSE, SBST and WMS-R) (P=0.004), abnormalities in P300 and higher depression scores (P=0.001). Comprehension, bead memory, memory for sentences, digit forward, digit backward, mental control, logical memory, total scores of cognitive testing, P300 amplitude and depression scores were markedly affected with poor glycemic control. Patients had high levels HbA1c and cortisol at basal state and after dexamethasone. This relationship was only significant in presence of poor glycemic control after controlling for age, duration of illness and dyslipidemia. We concluded that hypercortisolemia appears to exacerbate cognition dysfunction in T2DM only in presence of poor glycemic control.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Sherifa Ahmed Hamed Ahmad Hamdy Youssef Yaser Elserogy Omar Herdan Refaat Fathy AbdElaal Nabil AbdelHakim Metwaly Mahmoud Mohamad Hassan Hanan Omar Mohamad


Cognitive Neurology,Neurological disorder,Mild cognitive impairment,Diabetes Mellitus

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us