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Research Paper Open Access
A simple extractive photometric method for the determination of pyrithioxine from pharmaceutical preparation is described. The method involves extraction of drug-N-N-dimethyl-p-Phenylenediammonium dichloride and drug-paraphenylenediamine dihydrochloride complexes into chloroform after treatment with potassium ferricyanide in basic medium. The method also involves the determination of pyrithioxine with Folin and Ciocalteu's phenol reagent in basic medium. The absorbance of the coloured complexes were measured at the respective wavelengths of maximum absorbance. The methods are statistically validated and found to be accurate and precise.