alexa Abstract | Colorimetric Estimation for Salbutamol-sulphate in Pure Form and in Different Types of Pharmaceutical

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Research Article Open Access

Abstract

A new sensitive, simple and accurate colorimetric approach
is suggested of the estimation of salbutamol sulphate drug
in pure form, also in different types of pharmaceutical. The
approach is established on the conjunction of salbutamol
(SLB) drug and the reagent 4-aminoantipyrine (4-AAP)
reagent in basic medium to obtain a newly ligand that reacts
with cobalt (II) to produce highly intensity red colour
complex at 60°C. The water soluble dye is stable and
estimated colorimetric ally with maximum absorption at
500 nm. The calibration curve between the concentration
and the absorbance shows that the range of concentration
was applied by the Beer’s law between 2-60 μg/mL. The
optimization of the experiential circumstances is examined.
The precision and the accuracy for the approach are tested
by the average relative standard deviation values (1.32%)
and the average recovery values (100.23%) respectively.
That it is based on the concentration. The approach
sensitivity is obtained by molar absorptivity (0.6558×104
l.cm-1.mol-1). The sensitivity of Sandell is calculated (0.036
μg.cm-2). The analytical data for the approach is matched
with the standard method. The general interference from
drug additives was examined. The suggested approach is
successfully applied on the estimation of SLB in various
types of pharmaceutical.

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Author(s): Mohauman Mohammad ALRufaie Aymen Abdul Rasool Jawad and Hawraa Mohammed Sadiq

Keywords

Colorimetric, Estimation, Salbutamol sulphate, Pure form, Types of pharmaceutical

 
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