alexa Abstract | Combinational effects of n-hexane extract of poguntano leaves (Picria fel-terrae Lour.) with doxorubicin on MCF-7 breast cancer cells

Journal of Chemical and Pharmaceutical Research
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Abstract

Poguntano (Picria fel-terrae Lour.) leaves were extracted using n-hexane and examined cytotoxicity on MCF-7 cell line. Analysis data using SPSS 19 was showed that n-hexane extract has IC50 119,906 μg/ml and the value of cytotoxicity assay on Verro cell is < 3 showed that the extract is not selective. Cytotoxicity activity and combination of n-hexane extracted with doxorubicin were evaluated using the MTT assay. The combination represents higher inhibitory effect on cell growth than the single treatment of doxorubicin on MCF-7 cell lines.

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Author(s): Puji Lestari Sumadio Hadisahputra Syafruddin Ilyas and Denny Satria

Keywords

Combination, Picria fel-terrae Lour., cytotoxicity, MCF-7, doxorubicin

 
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