alexa Abstract | Comparative bioavailability studies of indomethacin from two-controlled release formulations in healthy albino sheep

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Paper Open Access

Abstract

The objective of the study was to obtain the pharmacokinetic data of two controlled release formulations of (75 mg) indomethacin and to compare the relative bioavailability of the test formulation (product B cetostearyl alcohol microspheres) with standard formulation (product A-Microcid®SR 75 mg capsule). A single dose randomized (4×2) complete cross over study of the indomethacin (75 mg) was carried out on 8 healthy albino sheep. The study was carried out on two separate occasions with a washout period of 2 weeks. Blood samples were collected at pre-determined time intervals. Plasma indomethacin concentrations and other pharmacokinetic parameters obtained were statistically analyzed. The results of the paired t-test for the comparison of pharmacokinetic data showed that there was no significant variation between the products A and B. Products did not show any significant difference between them with regard to the T max , C max , AUC 0-24 , AUCo-oo, MRT, Ka, Kel , K 1/2 , 3.0 h, 2054 ± 55.78 ng/ml, 9637 ± 132.87 ng h/ml, 9870 ± 129.22 ng h/ml, 4.76 ± 0.10 h, 0.3812 ± 0.002 h -1, 0.2713 ± 0.004 h -1, 2.55 ± 0.03 h -1, respectively for product A and 3.5 h, 1929 ± 20.32 ng/ml, 8343 ± 40.04 ng h/ml, 8617 ± 46.88 ng h/ml, 4.98 ± 0.02 h, 0.3648 ± 0.002 h -1, 0.2427 ± 0.010 h -1, 2.86 ± 0.20 h -1 for product B. From the dissolution studies and in vivo bioavailability studies, it was concluded that the products A and B are bioequivalent.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): DV Gowda HG Shivakumar

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords