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Research Paper Open Access
Imidazole was found to reduce urinary ascorbic acid excretion in rats unlike SKF 525-A. During one week daily treatment with imidazole (50 mg/kg, I.P.), ascorbic acid excertion was gradually reduced and the maximum reduction was 7.58 percent. With a single higher dose (100 mg/kg. I.P.) the reduction was 27.8 percent and was maintained later with further treatment. With SKF 525-A (50 mg/kg, I.P.), the ascorbic acid excretion was increased by 23.6 percent with a single dose and was raised to 68.54 percent after four doses which was maintained later on further treatment. The change produced in ascorbic acid excretion in rats by these substances was statistically significant.