alexa Abstract | Comparative Study of Intrathecal Midazolam and Ketamine with Bupivacaine for Post-Operative Analgesia in lower limb and perianal surgery

Biomedical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

Spinal anesthesia with bupivacaine is routinely administered for lower limb and perianal surgery. The ensuing nerve blockage is sufficient to provide adequate motor blockage, which facilitates the surgeon’s work and also provides effective pain relief during the initial postoperative period. In order to maximize post-operative analgesia, a number of adjutants have been added to local spinal anesthetics. Intrathecal supplements for post-operative pain relief are intriguing as they eliminate the need for intravenous and intramuscular analgesics and their associated complications. The objective of this study is to compare the intensity and duration of post-operative pain relief using intrathecal ketamine and midazolam with bupivacaine in patients undergoing lower limb and perianal surgery. This prospective, open label, parallel assignment, randomized, single-center trial, included eighty patients, who admitted for lower limb and perianal surgeries to the M.S. Ramaiah Medical College and Hospital, University- affiliated tertiary care center in Bangalore, India, were studied for 6 months. ASA (American Society of Anesthesiology) grade I and II patients between the ages of 20 and 60 years were included in this study. The onsets of action, intra-operative vital signs, postoperative vital signs, pain assessment by visual analogue scale, and post- operative analgesia time were recorded. A significantly higher VAS score were seen in group I (Ketamine). Postoperative analgesia was supplemented in all patients in group I at a mean duration of 482 ± 68.22 minutes and in group II at a mean duration of 645 61.28 minutes. The difference in mean post-operative supplemental analgesic time between the 2 groups was very highly significant (p < 0.001). Intrathecal midazolam with bupivacaine provides very good and prolonged post-operative analgesia compare to intrathecal ketamine with bupivacaine.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Abdul Muthali Hussain Badurudeen Mahmood Buhary Zikrullah Tamanna

Keywords

Analgesia, intrathecal analgesia, Ketamine, Midazolam, Post-operative analgesia

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords