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Original Articles Open Access
Lipid nanoparticles are promising carriers to deliver anticancer agents of low aqueous solubility such as Paclitaxel (PTX). The aim of this work is to improve the efficacy of Paclitaxel through formulation of Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC) containing two different liquid lipids. Preparation was done using homogenization and ultrasonication technique. Nanoparticles physical characterization was done by determination of the mean particle size, zeta potential and Transmission electron microscopy (TEM). Entrapment efficiency and Differential Scanning Calorimetry (DSC) was determined. In vitro release and cytotoxicity was done and results were compared to the commercially available product Taxol®.The mean particle diameter was between 276-314 nm, while zeta potential ranged from -20.2 and -24.9 mV. The entrapment efficiencies of prepared formulae were high(up to 87.6%) and thermal analysis revealed that the drug was in amorphous form. In vitro release through dialysis membrane showed prolonged release. In vitro cytotoxicity assay showed that IC50 of PTX-NLCs was significantly lower than that of Taxol®. NLC containing Capryol 90 had the best results in entrapment efficiency and lowest IC50. Both SLN and NLC can be potential carriers for prolonged release and to enhance activity of PTX.
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Author(s): Shady Ali Swidan Hassan Mahmoud Ghonaim Ahmed Mahmoud Samy and Mamdouh Mostafa Ghorab
Paclitaxel, Solid lipid nanoparticles, Nanostructured lipid carriers, Cytotoxicity, MCF7, in vitro Paclitaxel delivery