alexa Abstract | Comparative study of Vetiveria zizanioides and Foeniculum vulgare extracts on behavioral despair of Wistar albino rats

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

Mental depression is a major disorder of mood prevalent in a large percentage of the population and it disrupts the normal social life. The need of effective and well tolerated antidepressants has prompted to examine herbal plants that have been traditionally used for depression. Both Vetiveria zizanioides and Foeniculum vulgare are the common source of the well known oil, particularly used in aromatherapy and regarded as a tonic to the nervous system. Research showed the relationship between inflammation and depression and it is proved that both plants possess significant anti-inflammatory effect .So our aim is to compare the effects of the antidepressant drug fluoxetine and the combination of Vetiveria zizanioides and Foeniculum vulgare on depressive behavior in albino rats. Both Forced swimming test(FST) and Tail suspension test(TST) were used for screening antidepressant effect, The ethanolic extract of Vetiveria zizanioides(100mg/kg) and Foeniculum vulgare (200mg/kg) together, fluoxetine(10mg/kg) and saline were administered 30mts prior to the tests and the immobility period was recorded for 6mts.The antidepressant effect of both were compared to that of fluoxetine. Vetiveria zizanioides(100mg/kg) and Foeniculum vulgare (200mg/kg) produced significant antidepressant effect by reduction in immobility period as compared to control. But as a group together they are equally effective as fluoxetine (10mg/kg) The results of the present study indicated the antidepressant activity of Vetiveria zizanioides and Foeniculum vulgare and their potential for use of an adjuvant in depression.

To read the full article Peer-reviewed Article PDF image

Author(s): Glory Josephine I Arul Amutha Elizabeth Punnagai K and Muthiah N S

Keywords

Antidepressant, Forced swimming test, Tail suspension test, Vetiveria zizanioides, Foeniculum vulgare, Vetiveria zizanioides

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords