alexa Abstract | Comparison of Mannan-binding lectin-associated serine protease-2 (MASP-2) serum levels between children with acute lymphoblastic leukemia and healthy controls

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

Mannan-binding lectin-associated serine protease-2 (MASP-2) is an essential component of the lectin pathway of complement activation. Its serum concentrations show a wide interindividual variability. The aim of our study was to determine if serum concentrations of MASP-2 differ between children with Acute lymphoblastic leukemia (ALL) and healthy age-matched controls. This study included 48 individuals: 37 children with Acute lymphoblastic leukemia (ALL) and 11 healthy age-matched controls. Serum levels of MASP-2 were evaluated by ELISA. The results showed that children with Acute lymphoblastic leukemia had higher median MASP-2 serum concentrations (509 ± 351.8 ng/mL) compared to healthy age-matched controls (284 ± 35.4 ng/mL), (p<0.05). This indicates the Acute lymphoblastic leukaemia associated with high levels of MASP-2 and suggests the possibility to use MASP-2 as diagnostic biomarker for Acute lymphoblastic leukaemia.

To read the full article Peer-reviewed Article PDF image

Author(s): Ragheb Harb and Jumana Saleh

Keywords

Acute lymphoblastic leukemia (ALL), innate immunity, Mannose-binding lectin-associated serine protease-2 (MASP-2)., lymphoblastic leukemia

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords