alexa Abstract | Complexes Of Nifedipine With β-And Hydroxypropyl β-Cyclodextrins In The Design Of Nifedipine SR Tablets

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Paper Open Access

Abstract

Complex formation of nifedipine with β-cyclodextrin and hydroxypropyl β -cyclodextrin was studied. The possibility of improving the solubility and dissolution rate of nifedipine via complexation with the above cyclodextrins and the feasibility of employing nifedipine cyclodextrin inclusion complexes in the design of mucoadhesive tablets for sustained release were also investigated. The phase solubility studies indicated the formation of a nifedipine- β-cyclodextrin (1:1 M) and nifedipine-hydroxypropyl β -cyclodextrin (1:1 M) inclusion complexes with a stability constant of 121.9 M-l and 253.7 M-I respectively. The solubility and dissolution rate of nifedipine were rnarkedly enhanced by complexation with β-cyclodextrin and hydroxypropyl β -cyclodextrin. Nifedipinehydroxypropyl β -cyclodextrin (1:3) gave highest enhancement (44.8 fold) in the dissolution rate of nifedipine. Mucoadhesive tablets formulated employing nifedipine alone gave very low dissolution. Whereas those formulated employing nifedipine- β-cyclodextrin and nifedipine-hydroxypropyl β-cyclodextrin complexes gave slow, controlled and complete release spread over a period of 12 h. Drug release from these tablets followed zero order kinetics upto 85-90% release and the release was diffusion controlled. Good sustained release two layered tablet formulations of nifedipine, satisfying the theoretical sustained release need based on its pharmacokinetics, were developed using nifedipine-β-cyclodextrin and nifedipine-hydroxypropyl β -cyclodextrin inclusion complexes.

To read the full article Peer-reviewed Article PDF image

Author(s): K P R Chowdary G Kamalakara Reddy

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords