alexa Abstract | Computational analysis of coagulase protein from Staphylococcus Sp. Cobs2Tis23

Journal of Chemical and Pharmaceutical Research
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Abstract

Some of the Staphylococcus species were shown to have Coagulase properties. Earlier we reported a strain from Staphylococcus family named Staphylococcus sp. Cobs2Tis23 which possesses Coagulase properties. Since structure prediction by the bioinformatics tools depending upon its amino acid sequence is very important to have a preliminary knowledge about the characteristics of the protein before the experimental evidences by structural studies, we tried to predict the structural conformation as well as some biochemical characteristics of the coagulase extracellular protein present in Staphylococcus sp. Cobs2Tis23 strain. A range of bioinformatics programmes like Expasy, TranSeq ToxinPred, PROCHECK, ERRAT, Discovery Studio 4.0 were used for the structure prediction as well as the biochemical characterisation of the protein. A Ramachandran plot validated structure is predicted out for the Coagulase protein which is found to be nontoxic and have the molecular weight of 50049.7 Da. Prediction of the structural conformation of the protein also shows the protein have the isoelectric pH of 9.68 and has three binding sites.

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Author(s): Dibyajyoti Ozah Jatin Kalita Prasenjit Manna Tapan Dey Robin DasRobin Kumar Sharma and Balagopalan Unni

Keywords

Staphylocoagulase, in Silico Characterization, Structure, Toxicity Prediction, protein

 
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