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Research Paper Open Access
In this study microcapsules prepared from gum karaya (GK) and chitosan (CH) using the principle of complex coacervation for the first time with a continuous oil-phase were evaluated for their in vivo performance. Diclofenac sodium (DFS) was used as the drug of choice. The dissolution profiles of DFS from prepared microcapsules as well as commercial product followed non-Fickian diffusion. The formulation displayed a sustained in vivo blood level pattern that is comparable to that of a commercial controlled release formulation.
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Author(s): G V Murali Mohan Babu K Himasankar Cheruvu P S Narayan K V Ramana Murthy