alexa Abstract | Correlation of DNA damage and oxidative stress with organ dysfunction in perinatal asphyxia.

Current Pediatric Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

The current study was conducted to correlate the level of DNA damage with multiorgan dysfunction (MOD) in perinatal asphyxia. Among the 80 cases with MOD, 25% each of the babies had five and four organ system involvement , while 23.8% of babies had involvement of 3 systems and 26.3% had 2 organ system dysfunction. The DNA damage increased with the number of systems involved. The comet tail length increased from 24.76±3.203, 42.192±4.685, 57.40±4.246 and 90.734±2.485mm with two, three, four and five organ system dysfunction respectively. The percentage of DNA in tail of comet was also significantly higher with increase in number of system involved (p <0.001). There was significant positive correlation between %DNA in tail of comet and serum MDA level. It is concluded that oxidative stress and DNA damage have a linear correlation to MOD in perinatal asphyxia.

To read the full article Peer-reviewed Article PDF image

Author(s): A Manoj K Ramachandra Rao B Vishnu Bhat C Venkatesh Z Bobby

Keywords

Perinatal asphyxia, Multiorgan dysfunction(MOD),Comet Assay, Malondealdehyde(MDA).

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords