alexa Abstract | Cyclic AMP response element binding protein (CREB) in depression: A new role of an old molecule

Current Neurobiology
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

Depression is one of the most common and most devastating psychiatric disorders. Despite its high prevalence and socio-economic impact, little is known about its etiology. Preclinical and clinical studies have demonstrated that depression can lead to cell loss and atrophy in limbic brain structures including hippocampus. An emerging hypothesis suggests that the treatment of depression is likely to involve a plasticity of neuronal pathway. Although a variety of treatment strategies is available. A major problem in its therapy consists of unpredictability of its drug response. Antidepressant treatments may exert their therapeutic effects by stimulating appropriate adaptive changes in neuronal systems. A novel therapeutic approach consists of targeting signal transduction and gene expression pathways. One of the best investigated pathways is cyclic AMP messenger system which ultimately influences gene expression by activating the transcription factor cyclic AMP response element binding protein (CREB) via phosphorylation. Recent studies have demonstrated that cyclic AMPCREB system is disturbed in depression. This review focuses on the molecular mechanism underlying the effects of antidepressant treatment including adaptations in the cyclic AMP transduction cascade and also suggests that increased CREB activity may result in an improved neuronal plasticity, which in turn could contribute to amelioration of the clinical symptoms of depression.

To read the full article Peer-reviewed Article PDF image

Author(s): Sanjukta Misra

Keywords

Depression, Cyclic AMP transduction cascade, Cyclic AMP response element binding protein, antidepressant treatment

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords