alexa Abstract | Dendrimeric Nanoarchitectures Mediated Transdermal and Oral Delivery of Bioactives

Indian Journal of Pharmaceutical Sciences
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Review Article Open Access

Abstract

Transdermal route is an evolving panorama in novel drug deliverance and with oral route they proffer immense potential. Most recently there is hastening in approaches for delivering bioactives via these routes, amongst them revolution has been made by dendrimers. Encapsulation and conjugation of bioactives with these virus sized robots have shown immense employment for delivery of hydrophobic and labile remedies. Transport of these nano-cruises from corner to corner of skin and through epithelial hurdle of gastrointestinal tract depends upon dendrimer characteristics. An improved thoughtful of these characteristics is an obligation for their use in these rambling fields. These characteristics embrace generation size, molecular weight, surface charge, incubation time and concentration. This context demarcates the imperative role of dendrimers in transdermal and oral drug delivery. This review also highlights concerning mechanism of convey of nanoarrays via epithelial hurdle of GIT.

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Author(s): V Gajbhiye P Vijayaraj Kumar A Sharma A Agarwal A Asthana NK Jain

Keywords

PAMAM dendrimer, transdermal, oral, transcellular, paracellular

 
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