alexa Abstract | Design and characterization of mucoadhesive microspheres of novel NSAID drug using algino-eudragit RS100 system

Der Pharmacia Sinica
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


Mucoadhesive microspheres of aceclofenac was formulated using combination of alginoeudragit RS100 system by ionic gelation technique. The prepared microspheres were evaluated for various parameters like percentage yield, particle size, flow property, surface study, ex-vivo mucoadhesive study, in vitro drug release, etc. It was found that all formulations showed improved flow behavior as compared to pure drug, it was observed that on increasing the polymer concentration of formulations the entrapment efficiency and particle size were increased. The surface morphology study by SEM indicated that microspheres were spherical with rough outer surface. There was no interaction between the drug and the polymers, as studied by FTIR study. In vitro drug release study showed that on increasing polymer concentration the drug release of all the formulations were gradually decreased and the formulations followed zero order kinetics. Ex- vivo mucoadhesion study depicts that when the polymer concentration was increased the mucoadhesion nature was also increased. Therefore, it can be concluded that aceclofenac loaded algino-eudragit RS100 microspheres can be formulated for sustained drug delivery of aceclofenac.

To read the full article Peer-reviewed Article PDF image

Author(s): Nazia Khanam Anupam K Sachan Md Irshad Alam Sudhir S Gangwarand Chinmay Anand

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version