alexa Abstract | Design and Characterization of sustained release Microspheres of Acarbose

International Journal of Drug Development and Research
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Abstract

The present study was envisaged to reduce the dosing frequency and improve patient compliance by designing and evaluating sustained release microspheres of acarbose for effective control of type-II diabetes mellitus. Microspheres were prepared by emulsification solvent evaporation method using sodium alginate and HPMC K15M as sustained release agents. The prepared microspheres were evaluated for particle size, drug content, surface morphology, drug entrapment efficiency, flow properties, in vitro drug release and stability studies. The drug excipients compatibility was determined by FTIR studies. The surface morphology of prepared microspheres was measured by SEM and the particle size distribution was determined using an optical microscope. The particles were found to be discrete and spherical with the average particle size in the range of 91±1.24 to 207±1.49μm. The formed acarbose microspheres showed high drug entrapment efficiency of 74.01 to 88.9%. The effect of factors like concentration of polymer, emulsifying agent, stirring speed, alginate: HPMC ratio on drug entrapment efficiency, morphology and drug release was studied. In vitro results showed that the formulation F3 containing 1:1 ratio of sodium alginate and HPMC K15 M released maximum amount of drug i.e. 36.17% (pH 1.2) and 95.83% (pH 7.4) due to the proper cross linking between sodium alginate and HPMC K15 M.

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Author(s): Kaurav Hemlata Harikumar SL and Kaur Amanpreet

Keywords

Microspheres, Acarbose, Sodium alginate, HPMC K15M

 
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