alexa Abstract | Design and delivery of ophthalmic drugs : chemical approaches.

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Paper Open Access

Abstract

It is now realized that the process of ocular drug and delivery requires a thorough understanding of various anatomical,phyysiological and metabolic features of the eye, in addition to the physico-chemical properties of the drug. Ocular drugs and delivery systems are currently undergoing a process of design optimization due to inherent physiological and anatomical constraints of the eye leading to problems associated with absorption efficiencies of topically applied drugs. Typically, 3 percent or less of the instilled drug in the solution dosage form into the percorneal area is actually absorbed across the cornea 1,3. The poor availability of ocular solution dosage forms therefore led to an intensive search for alternate forms delivery of drugs 4,5: (a) approaches to prolong the contact time of the drug with the corneal surface, and (b) approaches to epithelium or by modifications of chemical structure of the drug molecule. Chemical modifications of the active molecule is often found promising and necessary in order to overcome various problems of ocular drugs pertaining to their: (a)pharmacokinetic insufficiencies, (b) transportability, and (c) site specificity. In the recent years,some significant improvements have been made in this direction. The purpose of this article is to present a brief review of two novel chemical approaches of drug design, soft drugs and site-specific chemical delivery systems. A brief discussion on how these approaches have been utilized to design affective, selective and safe ocular drug delivery systems for the treatment of various pathological conditions and diseases affecting the eye, including treatment of glaucoma, ocular inflammations and infections is presented in this article.



Author(s): IK Reddy N Bodor

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords