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Original Articles Open Access
Bioadhesive polymers and other excipients were used to develop buccal tablet of terbutaline sulphate. In this research, the effect of bioadhesive polymers HPMC K100M, ethyl Cellulose, carbopol and sodium carboxy methyl cellulose were studied. Direct compression method was followed for the formulation and characterized by various evaluation parameters, some of which are hardness, thickness, drug content, friability, hardness, weight variation, thickness in-vitro bioadhesion, in-vitro swelling index and in-vitro drug release etc. In-vitro drug release was performed on USP type II dissolution apparatus at 50 rpm in 900ml of dissolution media (simulated salivary fluid pH 6.75) for 8 hrs. Carbopol was very helpful and important polymer for current study. Carbopol promote the bioadhesion and swelling index although controls the drug release.
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Author(s): Rajesh Asija Shailendra Bhatt Sangeeta Asija Deepak Sharma Gaurav Goyal andDolly Prakash Chand
Bio-adhesion, Swelling index, Drug release, Terbutaline sulphate, Simulated salivary fluid., Medicine, Tablet production