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Research Paper Open Access
Ciprofloxacin hydrochloride ocuserts were prepared using different polymers in various proportions and combinations. The in vitro release of the drug from the formulations was studied using a commercial semipermeable membrane. The physico-chemical parameters of the ocuserts were evaluated. A zero order release formulation VI (Drug reservoir with 2% HPMC and 6% EC as rate controlling membrane) was subjected to in vivo studies using rabbits. The results indicated a good correlation between in vitro and in vivo studies. The expected release for an extended period of 24 hours was observed in formulation VI (Drug reservoir with 2% HPMC and 6% EC as rate controlling membrane).
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Author(s): S Saisivam R Vijaya Muthu Manikandar M Nagarajan