alexa Abstract | Design And Evaluation Of Ciprofloxacin Hydrochloride Ocuserts

Indian Journal of Pharmaceutical Sciences
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Research Paper Open Access

Abstract

Ciprofloxacin hydrochloride ocuserts were prepared using different polymers in various proportions and combinations. The in vitro release of the drug from the formulations was studied using a commercial semipermeable membrane. The physico-chemical parameters of the ocuserts were evaluated. A zero order release formulation VI (Drug reservoir with 2% HPMC and 6% EC as rate controlling membrane) was subjected to in vivo studies using rabbits. The results indicated a good correlation between in vitro and in vivo studies. The expected release for an extended period of 24 hours was observed in formulation VI (Drug reservoir with 2% HPMC and 6% EC as rate controlling membrane).

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Author(s): S Saisivam R Vijaya Muthu Manikandar M Nagarajan

 
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