alexa Abstract | Design And Evaluation Of Mucoadhesive Controlled Release Oral Tablets Of Glipizide

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Paper Open Access

Abstract

Matrix tablets of glipizide were formulated using two mucoadhesive polymers namely sodium carboxymethylcellulose and hydroxypropylmethylcellulose and with and without ethylcellulose and the tablets were evaluated. Tablets formulated employing sodium carboxymethylcellulose or hydroxypropylmethylcellulose and with ethylcellulose provided slow release of glipizide over a period of 12 h and were found suitable for maintenance portion of oral controlled release tablets. Glipizlde release from these tablets was diffusion controlled and followed zero order kinetics after a lag time of 1 h and up t o 90 per cent release. The matrix tablets exhibited good mucoadhesion in the small intestine for 10 h as evaluated by X-ray studies. Two layered tablet formulations, designed with an immediately releasing layer consisting of glipizide and a super disintegrant (Ac-Di-Sol) and a slow releasing matrix consisting of glipizide in sodium carboxymethylcellulose or hydroxypropylmethylcellulose and ethylcellulose as second layer, gave release close to the theoretical sustained release needed for glipizide based on its pharmacokinetic parameters.

To read the full article Peer-reviewed Article PDF image

Author(s): KPR Chowdary G Balatripura Sundari

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us