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Research Paper Open Access
Propranolol hydrochloride buccal films were prepared using three different polymers in various proportions and combinations. The physicochemical parameters like weight variation, thickness, folding endurance, drug content, percentage moisture absorption and percentage moisture loss were evaluated. An in vitro study was designed and it was carried out using commercial semipermeable membrane. In vitro release profile for the formulation F6 (drug reservoir with 6% ethyl cellulose (EC)+ 0.5% polyvinyl pyrolidone (PVP) and 8% EC as rate controlling membrane) showed sustained release upto 24 h. It also obeyed first order kinetics. The studies conducted in rabbits confirmed the sustained release.
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Author(s): S Raghuraman G Velrajan R Ravi B Jeyabalan D Benito Johnson V Sankar