700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ ReadersThis Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Original Articles Open Access
The purpose of this research was to develop a matri x-type transdermal therapeutic system containing drug Aceclofenac with different ratios o f hydrophilic (hydroxyl propyl cellulose) and hydrophobic (ethyl cellulose) polymeric systems by the solvent evaporation technique by using 15 % w/w of dibutyl phthalate to the polymer weight , incorporated as plasticizer. Different concentrations of oleic acid and isopropyl myristat e were used to enhance the transdermal permeation of Atenolol. Formulated transdermal film s were physically evaluated with regard to thickness, weight variation, drug content, flatness , tensile strength, folding endurance, percentage of moisture content and water vapour tra nsmission rate. All prepared formulations indicated good physical stability. In-vitro permeat ion studies of formulations were performed by using Franz diffusion cells. Formulation prepared w ith hydrophilic polymer containing permeation enhancer showed best in-vitro skin perme ation through rat skin (Wistar albino rat) as compared to all other formulations. The results followed the release profile of Aceclofenac followed mixed zero-order and first-order kinetics in different formulation. However, the release profile of the optimized formulation F4 (r2 = 0.993 5 for Higuchi) indicated that the permeation of the drug from the patches was governed by a diff usion mechanism. These results indicate that the formulation containing the F4 [CAP: PVP (6:1)] has shown optimum release in concentration independent manner.
To read the full article Peer-reviewed Article PDF
Author(s): Ganesh Sheshrao Bangale B Stephen Rathinaraj Rajesh K S Gajanan V ShindeDeepak G Umalkar Ch Rajveer D Kumaraswamyand Preetha S Panicker
Atenolol, Transdermal Film, Permeation enhancer, In-vitro permeation study., Atenolol