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Gastroretentive dosage forms have potential for use as controlled release drug delivery systems. A Controlled release system designed to increase its residence time in stomach without contact with mucosa was achieved through the preparation of repaglinide floating tablets by direct compression method. In the present study, repaglinide an anti-diabetic agent was formulated into floating tablets by direct compression method using polymers such as different grades of Hydroxypropyl methylcellulose (HPMC) polymers such as HPMC K4M, K15M and K100M, sodium alginate and Carbopol 934P. Sodiumbicarbonate was used as gas generating agent. The floating tablets were evaluated for their physico-chemical properties, in-vitro release and stability studies. The order of Swelling index was found to be Carbopol 934P > sodium alginate > HPMC K100M > HPMC K15M > HPMC K4M. Sodium bicarbonate at the concentration of 14 %w/w was found to be ideal in achieving the buoyancy. The buoyancy lag time was found to be less than 1 minute. In all the five formulations prepared, formulation F4 (sodium alginate) was selected as best formulation as it released 94.39% of drug in a period of 24 hrs. Tablets followed diffusion controlled first order kinetics.
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Author(s): Md Sarfaraz B LingaReddyH DoddayyaUdupi Rajagopal H
Repaglinide, HPMC, Sodiumalginate, Carbopol 934P, Buoyancy, Swelling index, In-vitro release.