alexa Abstract | Design and synthesis of some novel 4-(4-substituted aryl) semicarbazones as anticonvulsant agents

Indian Journal of Pharmaceutical Sciences
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Abstract

In the present study, a series of 4-(4-substituted aryl) semicarbazones were synthesized from substituted anilines and subsequently evaluated for their anticonvulsant activities. The anticonvulsant activities were established by the anticonvulsant drug development (ADD) programme NIH, USA using experimental animal, adult male FCM mice (20-25 g) and adult Sprague-Dawley rats (100-150 g) and screened against electroshock seizure, subcutaneous metrazole and minimal neurotoxicity tests in mice. Compound 7 was found equipotent to carbamazepine in both MES and ScPTZ tests. This study has highlighted the importance of distal alkyl chain which influences the anticonvulsant activity.

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Author(s): Anita Singh C Pande P Gahtori SN Pandeya JP Stables

Keywords

Anticonvulsant, hydrogen bonding domain, lipophilic aryl/alkyl ring, 4-substituted semicarbazone

 
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