alexa Abstract | Design, Development And Evaluation Of Aceclofenac Sustained Release Matrix Tablets

International Journal of Drug Development and Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

In the present study “once daily” sustained release tablet of Aceclofenac has been developed. The study was designed to formulate, develop and evaluate an Aceclofenac sustained release tablets using HPMC of various grades as polymer as release retarding agent. Preformulation study of Aceclofenac was done initially and results directed for the further course of formulation. Based on preformulation studies different batches of tablet have been prepared by wet granulation method by using selected excipients. Granules were evaluated for various tests before being punched as tablets. Tablets were tested for weight variation, thickness, hardness and friability as per official procedure. Dissolution of batch T-8 was carried out in phosphate buffer pH 6.8 media and compared with marketed preparation. Based on dissolution tests and F-2 (similarity factor) values in pH 6.8 phosphate buffer as release medium, it was concluded that T-8 satisfactory performs in the same manner as that of marketed formulation. F-2 (similarity factor) value of T-8 was found to be optimized. From the results obtained it is concluded that formulation of sustained release tablet of Aceclofenac containing HPMC K 15M in the ratio of 200: 23 (in mg), T8 can be taken as an ideal or optimized formulation of sustained release tablets for 24 hour release as it fulfills all the requirements for sustained release tablet. The drug release from these formulations was satisfactory after 2 months storage in 400 C and 75% RH. Besides, this study explored the optimum concentration and effect of polymer(s) on acelofenac release pattern from the tablet matrix for 24 hour period

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Sharma Ankita Shukla Tarkeshwar Indoria Manish Dev Jha Sajal Kumar

Keywords

Aceclofenac, Matrix tablets, Sustained release, Wet Granulation, Hydroxy Propyl Methyl Cellulose (HPMC), F-2 (similarity factor).

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords