alexa Abstract | Design fabrication and characterization of controlled released tablets of Trimetazidine di hydrochloride

Der Pharmacia Sinica
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


The purpose of the present study was to formulate the oral controlled release Trimtazidine di hydrochloride tablets by using HPMC and Xanthan gum as rate controlling polymer. The tablets were prepared by direct compression method. The powder mixtures were evaluated for angle of repose, loose bulk density, tapped bulk density and compressibility index, shows satisfactory results. All the ingredients were lubricated and compressed using 8mm circular shaped deep concave punches. Compressed tablets were evaluated for uniformity of weight, content of active ingredient, thickness, friability, hardness and In-vitro dissolution studies. Drug content in formulation was determined by UV Method. All the formulation showed compliance with Pharmacopoeial standards. The in vitro release study of matrix tablets were carried out in 0.1N Hydrochloric acid with pH 1.2 for 10 hours. Formulation F1, F2, F4 and F5 failed to sustain release beyond 10 hours. Among all the formulation, F3 shows 99.63 % release at the end of 10 hours. It was observed that the amount of polymer influences the drug release. In vitro release study results revealed that the release of drug was retarded with the proportional increase of the polymer concentration.

To read the full article Peer-reviewed Article PDF image

Author(s): Masadi Rajukar Tejendra Vaka K Hygreevachary Ennam Venkateswarlu andKandagatla Rakesh

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version