alexa Abstract | Design, formulation and in-vitro characterization of Irbesartan solid self-nanoemulsifying drug delivery system (S-SNEDDS) prepared using spray drying technique

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access


The main objective of this study was to develop solid self-nanoemulsifying drug delivery system (S-SNEDDS) of Irbesartan (IRB) for enhancement of its solubility and dissolution rate. In this study, a novel liquid SNEDDS containing Irbesartan was formulated and further developed into a solid form by spray drying technique using Aerosil 200 as solid carrier. The solubility of IRB was determined in various oils, surfactants and co-surfactants to select the best candidates for IRB for further study. Pseudoternary phase diagrams were constructed to identify the efficient area of self-nanoemulsification. Based on preliminary screening of different unloaded SNEDDS formulae, eight formulae of IRB loaded SNEEDS were prepared using Capryol 90, Cremophor RH40 and Transcutol HP as oil, surfactant and cosurfactant respectively. The optimized IRB loaded SNEDDS formulae were evaluated for effect of dilution (with different volumes at different pH values), efficiency of self-emulsification, viscosity, optical clarity, morphological characterization, drug loading efficiency, in-vitro drug release, droplet size analysis as well as polydispersity index (PDI). SNEDDS formulae were also tested for thermodynamic stability and zeta potential to confirm the stability of the prepared SNEDDS. Results showed that the mean droplet size of all reconstituted SNEDDS was found to be in the nanometric range with optimum PDI values. All formulae also showed rapid emulsification time, good optical clarity, and high drug content; and found to be highly stable. Transmission electron microscopic images showed the formation of spherical and homogeneous droplets with a size smaller than 50nm, which satisfies the criteria of nanometric size range required for nanoemulsifying formulae. In-vitro release of IRB from SNEDDS formulae showed that more than 99% of IRB release in approximately 90 minutes. Optimized SNEDDS formulae with the smallest particle size, rapid emulsification time, best optical clarity, and maximum drug content and rapid in-vitro release were selected to be developed into solid self-nanoemulsifying drug delivery system (S-SNEDDS) using spray drying technique. The prepared S-SNEDDS formulae were evaluated for flow properties, differential scanning calorimetry (DSC), scanning electron microscopy (SEM), reconstitution properties, drug content and in-vitro dissolution study. It was found that S-SNEDDS formulae showed good flow properties and high drug content. Reconstitution properties of S-SNEDDS showed spontaneous self-nanoemulsification and no sign of phase separation. DSC thermograms revealed that IRB was in solubilized form and FTIR supported these findings. SEM photographs showed smooth uniform surface of S-SNEDDS with less aggregation. Results of the in-vitro drug release showed that there was great enhancement in dissolution rate of IRB.

To read the full article Peer-reviewed Article PDF image

Author(s): Ali M Nasr Ahmed R Gardouh Hassan M Ghonaim and Mamdouh M Ghorab


Solid Self-nanoemulsifying drug delivery system (S-SNEDDS), Irbesartan, Spray drying, Aerosil 200, Capryol 90, Cremophor RH40 and Transcutol HP, spray drying technique

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version