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The present study was designed to develop a suitable matrix type transdermal drug delivery system (TDDS) of Aceclofenac using blends of three different polymeric combinations of Polyvinyl pyrrolidine (PVP) and ethylcellulose (EC). Physical studies including moisture content, moisture uptake, flatness to study the stability of the formulations and in vitro dissolution of the experimental formulations were performed. It was observed that as the concentration of the hydrophilic polymer, PVP, increased in the formulation, the rate of dissolutions increased subsequently and the best result found for the polymer ratio 3:5. From the study of release mechanism it was found that the higuchi plot showed reasonably straight line with high correlation coefficient. It was also found that there were no significant reactions developed during the contact of patch with the dermis. Hence, it can be reasonably concluded that Aceclofenac can be formulated into the transdermal matrix type patches to sustain its release characteristics and the polymeric composition (PVP/EC, 3:5) was found to be the best choice for manufacturing transdermal patches of Aceclofenac among the formulations studied.
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Author(s): IRFAN NEWAZ KHANA MARZINA AJRINA MD RAZIBUL HABIBB MARIA ISLAM KHANA MD MOMINUR RAHMANB MOHAMMAD SHOHELC
Aceclofenac, Transdermal Patch, PVP, Ethylcellulose