alexa Abstract | Design, synthesis and biological evaluation of novel diphenylthiazole-thiazolidin-4-one-based derivatives as anti-inflammatory/analgesic agents

Journal of Chemical and Pharmaceutical Research
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Original Articles Open Access


A series of novel diphenylthiazole-thiazolidin-4-one-based derivatives was synthesized and characterized by elemental and spectral analysis. The newly synthesized compounds were screened for their analgesic and anti-inflammatory activities using acetic acid-induced writhing test and carrageenan-induced edema assay, respectively. Among the compounds, compound 13 was found to be the most potent analgesic and anti-inflammatory agent among the newly synthesized compounds compared to the standard drug, diclofenac.

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Author(s): Ahmed H Abdelazeem Mohammed T ElSaadi Asmaa G Safi ElDin and Samir M ElMoghazy


diphenylthiazole, thiazolidin-4-one, anti-inflammatory, analgesic., analgesic

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