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Original Articles Open Access
Aliphatic polyester elastomers have emerged as a promising family of biomaterials for drug delivery and tissue engineering. The potential biomaterials should be elastic and flexible, so as to mimic the mechanical properties of natural tissue. Herein, we report the design and synthesis of elastomers containing multifunctional non-toxic monomers; citric acid (CA), 1,4-cyclohexanedimethanol (CHDM) 1,12-dodecanediol and itaconic acid (IA). CA as a reactive monomer can undergo polycondensation in the absence of toxic catalyst. Also, its multifunctionality can favour the formation of crosslinks during thermal curing conditions. The polyesters were characterized using FT-IR and NMR spectroscopy. The thermal properties were studied using DSC and TGA techniques. The Young’s modulus, UTS, % elongation and swelling experiments revealed that the mechanical and swelling characteristics of the polyesters could be controlled by modifying the monomers. The solubility tests revealed that the pre-polymers were soluble in common organic solvents therefore facilitating processing ability for different applications. The insolubility of post-polymerised polyesters confirmed that they were elastomers this result was evidenced by the Tg which were well below the body temperature. As all the monomers used in these materials have previously been utilized in other biomaterials the synthesized elastomers could be excellent candidates as future biomaterials.
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Author(s): J Margaret Marie R Puvanakrishnan and R Nanthini
Citric acid, 1,12-dodecanediol, 1,4-cyclohexanedimethanol, bioelastomer, polyester, itaconic acid