alexa Abstract | Design, synthesis and discovery potent of novel anticancer agents based on the coumarin scaffold

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

Several effective anticancer therapeutic drugs containing coumarin nucleus targeting carbonic anhydrase enzyme. Thus, some coumarin derivatives 1-22 were prepared. The structures of these compounds established on the basis of IR, 1HNMR, 13CNMR and MS data. Moreover, the optimization geometries for compounds 1-22 were discussed using DFT theory with B3LYP\6-311G base set. The molecular docking simulations into the active site of COX-2 were performed, and showed that, some compounds (7,8, 11,13,19b and 20) suitable inhibitor against CAII, and can used as anti-cancer drugs. These compounds (7,8, 11,13,19b and 20) were evaluated against Ehrlich solid carcinoma (EAC) tumor model in Swiss albino mice on dose 50μg . The activity was assessed using survival time and average increase in body weight, which showed that, administration of derivatives (7,8, 11,13,19b and 20) were effective in reducing solid tumor mass EAC cells. In silico, The ADMET profiles showed that, these compounds are good oral bioavalability, and the most active compounds 6 and 10 are CNS active agents without marked health effects observed for rodent

To read the full article Peer-reviewed Article PDF image

Author(s): A A Elhenawy Mona Sayed Kadh Azza Radwan Reda D AbdElghanyand M K Hassanein

Keywords

anticancer agent, coumarin, NMR Spectra

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords