alexa Abstract | Design, synthesis and hypoglycemic activity of novel 2-(4-((2, 4- dioxothiazolidin-5-ylidene) methyl)-2-methoxyphenoxy)-N- substituted acetamide derivatives

European Journal of Experimental Biology
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Research Article Open Access

Abstract

The work reports facile synthesis of novel 2-(4-((2, 4-dioxothiazolidin-5-ylidene) methyl)-2-methoxyphenoxy)-Nsubstituted acetamide derivatives 3(a-o), accomplished in good yields in three steps, using conventional, mild reaction conditions. The synthesized compounds were evaluated for their hypoglycemic activity in Wister albino mice animal model and histopathological studies of kidney and liver were performed to check the toxicity effects of the synthesized derivatives. All derivatives have shown significant hypoglycemic activity.

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Author(s): Anna Pratima G Nikaljea Sagar Choudharia and Hemant Une

Keywords

Thiazolidinedione, acetamide, hypoglycemic activity, Alloxan-induced diabetes, Thiazolidinedione, acetamide, hypoglycemic activity, Alloxan-induced diabetes

 
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