alexa Abstract | Design, synthesis and molecular docking studies of azido-pyrimidine analogues as anti-bacterial and anti-fungal agents

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access


As part of our exploration for new antibacterial and antifungal agents, a series of 2-(2-amino-5-azido-6- phenylpyrimidin-4-yl)-4-substituted phenols hybrids were synthesized. Simulation of virtually designed 25 compounds have been studied for their binding active sites of tyrosyl-tRNA synthetase (TyrRS) and cytochrome P450 14-sterol demethylase CPY51 enzyme using molecular modeling of protein– ligand interactions to predict drug structure–activity relationship. For comparison, the binding behavior of known standard drugs has also been studied. Synthesized compounds were screened for their in vitro antibacterial activity against Staphylococcus aureus, Salmonella typhi, antifungal activity against the opportunistic pathogens Candida albicans and Aspergillus niger. The objective of our research is to accept the challenge of discovery of new drug. To ensure the desired target specificity and potency, bioavailability and lack of toxicity, our approach stems out lead generation from virtual screening to their synthesis and ends up with biological assays.

To read the full article Peer-reviewed Article PDF image

Author(s): Nitin K Longadge Anjali M Rahatgaonkar and Binda D Saraf


Azidopyrimidines, Ionic liquid, Docking, tyrosyl-tRNA synthetase (TyrRS), cytochrome P450, Antimicrobial activity.

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version