alexa Abstract | Design, synthesis, characterization and DNA interaction of new Schiff base metal complexes

Journal of Chemical and Pharmaceutical Research
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Abstract

A new set of Schiff base complexes derived from thenil and 1,3-diaminepropane have been synthesized and characterized by infrared (IR), mass and UV–Visible spectral analysis. The spectroscopic data of metal complexes indicated that the metal ions are complexed with azomethine nitrogen atoms. The interaction of the synthesized complexes with CT (Calf - Thymus) DNA was investigated by utilizing absorption, fluorescence spectroscopy (ethidium bromide displacement assay) Viscosity and Circular dichroic analysis. The obtained results suggest that the complexes synthesized bind to DNA via an intercalative mode and can quench the fluorescence intensity of EB bound to DNA. Considerable hypochromicity and red shifts were observed in the UV absorption band of the synthesized complexes. Binding constants (Kb) of DNA with the complexes were calculated to be 5.01 x 104 M-1, 3.93 x 104 M-1 and 3.45 x 104 M-1. and Kapp of 5.82 x 105 M-1, 4.86 x 105 M-1 and 4.04 x 105 M-1.

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Author(s): M Maria Dorathi Anu S Iyyam Pillai C Joel R Biju Bennie S Subramanianand S Damodar Kumar

Keywords

Thenil, 1,3-diaminepropane, DNA binding, Intercalative mode, Schiff base, Schiff base

 
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