alexa Abstract | Determination of ambroxol hydrochloride using dithiocarbamic acid colorimetric method

Indian Journal of Pharmaceutical Sciences
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A new simple, colorimetric method was developed on the basis of a chemical reaction of amine group in ambroxol hydrochloride with carbon disulphide to form dithiocarbamic acid, which on further reaction with cupric chloride forms a colored copper chelate. The yellowish-orange chromophore has absorption maxima of 448 nm and obeys Beer's law in the concentration range of 10-100 µg/ml. Results of the analysis were statistically validated by recovery studies. The method was found to be suitable for routine determination of ambroxol hydrochloride in tablet formulation.

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Author(s): PNS Pai N Lalitha B Balakrishna GK Rao

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