alexa Abstract | Determination of ciprofloxacin in pharmaceutical formulations using HPLC Method with UV Detection

Indian Journal of Pharmaceutical Sciences
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Abstract

A simple, specific, accurate and rapid reversed phase high performance liquid chromatographic method was validated for the determination of the content of ciprofloxacin in three pharmaceuticals forms: generic, similar and compounded. The results of the validation showed that the method was highly efficient for quantification of ciprofloxacin in the matrices evaluated. The recovery rates were between 97.4 to 104.3 %, and the relative standard deviations were lower than 5 % for repeatability, and lower than 5.15 % for intermediate precision. The limits of detection, quantification and practical, were 0.11, 0.35 and 1.56 μg/ml, respectively. All compounded samples were approved with in the quality control; however, one generic and one similar sample presented above allowed level.

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Author(s): R Scherer Jessica Pereira Juliete Firme Mariana Lemos Mayara Lemos

Keywords

Quality control, ciprofloxacin, quinolones, HPLC, antibiotics

 
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