alexa Abstract | Determination of etoricoxib in pharmaceutical formulations by HPLC method

Indian Journal of Pharmaceutical Sciences
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Abstract

A simple, precise and rapid RP-HPLC method was developed for the estimation of etoricoxib in pharmaceutical dosage forms. The method was carried out on a Kromasil 100, RP-C18 column using a mixture of acetonitrile: methanol: 10mM potassium dihydrogen phosphate (pH 3.0 adjusted with orthophosphoric acid). The detection was carried out at 234 nm using rofecoxib as an internal standard. The linearity was found to be 25 to 400 ng/injection with correlation coefficient of 0.9996. The intra-day and inter-day precision (% RSD) were in the range of 0.28 to1.26 and 0.35 to 1.39, respectively. The percentage recovery was found to be 99.52±1.51 to 100.59±1.16. The result of analysis of marketed formulation was found to be 100.32±0.96 to100.95±0.69. The proposed method was successfully applied for the estimation of etoricoxib in pharmaceutical dosage forms.

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Author(s): HM Patel BN Suhagia SA Shah IS Rathod

 
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