alexa Abstract | Determination of montelukast sodium and bambuterol hydrochloride in tablets using RP HPLC

Indian Journal of Pharmaceutical Sciences
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Abstract

An accurate, specific and precise assay level gradient reverse-phase high-performance liquid chromatographic method was developed for simultaneous determination of montelukast sodium and bambuterol hydrochloride in tablet dosage form. An inertsil ODS C-18, 5 µm column having 250×4.6 mm I.D. in gradient mode, with mobile phase A, containing 0.025 M sodium phosphate buffer: methanol (85:15) and mobile phase B, containing acetonitrile:methanol (85:15) was used at different time intervals. The flow rate was 1.5 ml/min and effluent was monitored at 218 nm. The retention times of montelukast sodium and bambuterol hydrochloride were 21.2 min and 5.8 min respectively. The linearity for both the drugs was in the range of 0.25-0.75 mg/ml with correlation coefficients of 0.9999 and 0.9996 for montelukast sodium and bambuterol hydrochloride, respectively.

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Author(s): Smita Patil YV Pore BS Kuchekar Aruna Mane VG Khire

Keywords

Montelukast sodium, bambuterol hydrochloride, HPLC, simultaneous, dosage form

 
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