alexa Abstract | Determination of naltrexone based on its enhancement effect in the chemiluminescence reaction of Ru (phen)3 2+ with acidic cerium(IV)

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

This work establishes a simple method for the determination of naltrexone by chemiluminescence (CL) technique. This method is based on the enhancement effect of naltrexone on the weak CL emission raised from reaction between tris(1,10 phenanthroline)ruthenium(II), Ru(phen)3 2+, and cerium(IV) (Ce(IV)). Under the optimum chemical conditions, CL intensity was correlated linearly with concentration of naltrexone in the range of 0.07-13.7 μg mL-1 with a correlation coefficient of 0.9990. The detection limit for this drug was calculated 0.06 μg mL−1 (3:1 signal-to-noise ratio) and the relative standard deviation for 10 repetitive determinations of 1.37 μg mL-1 naltrexone was 5.3 %. The method was applied to the determination of naltrexone in human plasma and the results were in good agreement with the spiked values.

To read the full article Peer-reviewed Article PDF image

Author(s): Maryam Koohsariana Ali Mokhtari Shabnam Hooshmanda Jalal Niazia Mohsen Keyvanfardb Masoud Yavaria and Ahmad Kiaalvandia

Keywords

Chemiluminescence, Naltrexone, Time resolve, Plasma, naltrexone

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us