alexa Abstract | Determination of pyrimethamine in drug preparations by fluorimetry.

Indian Journal of Pharmaceutical Sciences
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Research Paper Open Access


A simple and sensitive fluorimetric procedure is described for the analysis of pyrimethamine in dosage forms depending on its strong fluorescence in 1 normal sulphuric acid (lamda excitation = 321 nm, (lamda emission = 425 nm) with a detection limit of 1 mug/ml. The addition of molecules of sulfodoxine cause a quenching in the region of excitation and emission of the former compound.

Author(s): P Parimoo

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