alexa Abstract | Development & optimization of fast Dissolving tablet of levocetirizine HCL

International Journal of Drug Development and Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

Levocetirizine (as Levocetrizine hydrochloride) is a third-generation non-sedative antihistamine, developed from the second-generation antihistamine Cetirizine. Levocetirizine Hcl works by blocking histamine receptors. It does not prevent the actual release of histamine from mast cells, but prevents it binding to its receptors. Fast dissolving tablets of Levocetrizine HCl were prepared using sodium starch glycolate, Croscarmellose sodium and Crosspovidone as superdisintegrants by direct compression method. The tablets prepared were evaluated for various parameters like weight variations, hardness, friability, in vitro dispersion time, drug content, wetting time, in vitro drug release, FTIR and XRD. The tablets prepared by direct compression method possess a weight variation below ±7.5%, hardness of 3 to 4.0 Kg/cm², percentage friability of 0.51 to 0.85, in vitro dispersion time of 17 to 58 seconds, Wetting time of 13 to 48 seconds, and in vitro drug release showed 94% to 99.00% within 20 min. The formulation (MD6) contains Crosspovidone and Sodium Starch Glycolate shows better Disintegration time and 99% drug release within 20 min.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Mehul Dekivadia Avinash Gudigennavar Chandrashekar Patil Bhaskar Umarji

Keywords

In vitro dispersion time, Levocetrizine HCl, Fast dissolving tablets, Superdisintegrants

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords