alexa Abstract | Development and evaluation of an ocular niosomal delivery system for some newly synthesized Beta blockers

Asian Journal of Biomedical and Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

Topical beta-blocking agents are nowadays the drugs of choice as these have few ocular and systemic side effects. In the present study some selected beta blockers (PP-24, PP-34, PP-41, PP-48, PP-50), synthesized using 4-hydroxybenzaldehyde and isovanillin were encapsulated into niosomes possessing a high drug entrapment efficiency in order to be used as ophthalmic carriers for topical ocular treatment. Prepared niosomes were characterized for morphology, number of vesicles per cubic millimeter, entrapment efficiency and drug content. Incorporation of the drug into respective niosomal preparation was confirmed by DSC. TEM studies showed that vesicles were small in size, round in shape, bilamellar/unilamelar without any aggregation. No significant variation in particle size and drug content of prepared niosomes was observed, upon storage, over a period of 42 days at 4-8°C. Ex vivo permeability studies indicated that PP-24 formulation showed the maximum enhancement in corneal permeability (27.29%) as compared to the free drug (11.33%). Onset of action of all the developed formulations was 0.5 h which was comparable to timolol. Formulation PP-24 produced sustainable and better IOP lowering effect than formlation PP-34. This may be attributed to lower particle size and better entrapment efficiency of the PP-24 niosomal formulation.

To read the full article Peer-reviewed Article PDF image

Author(s): Piplani P Kumar P Rohilla A Singla S Kaur IP

Keywords

Ocular niosomal

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords