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Research Paper Open Access
Lignocaine hydrochloride was formulated as a buccal tablet to provide prolonged relief from pain associated with tooth extraction. The tablet was prepared using suitable mucoadhesive polymers. Optimized tablets contained lignocaine hydrochloride 15 mg, Carbopol-934P 15.2 mg, sodium carboxy methyl cellulose 60.8 mg, mannitol 4 mg, Polyvinyl pyrrolidone-K30 5 mg, magnesium stearate 2 mg, saccharin sodium 0.2 mg and mint flavor (dried) 0.1 mg. Dissolution studies showed 86.66% release of drug in 360 min. Bio-adhesive strength was found to be 31.96 g. Adhesion time was greater than 6 h. Surface pH was found to be 7.02. The formulation was also subjected to in vitro permeation studies, in situ release studies, in vitro swelling studies and in vivo evaluation in healthy volunteers. The optimized tablets were also subjected to other quality control tests. Stability studies showed that the formulation was stable for more than two years.
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Author(s): N Parviez Alka Ahuja R K Khar