alexa Abstract | Development and evaluation of novel Fluticasone Propionate Emulgel for topical drug delivery

Journal of Chemical and Pharmaceutical Research
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Abstract

The studies were conducted with an object to develop even, harmless and efficient delivery system for Fluticasone Propionate. Topical drug delivery has gained a marvellous interest in today’s pharmaceutical formulation and research is going on in achieving better product. Fluticasone Propionate is corticosteroids with anti-inflammatory medication that is generally used to treat eczema and dermatitis. Emulgel is a semi solid preparation which decreases the systemic side effects and to create a more pronounced effect with lower doses of the drug. Emulsion in gel have emerged as one of the most interesting topical drug delivery system as it has twofold release control system. Also the stability of emulsion is increased when it is incorporated into gel. The Emulgel was developed using polymers like Carbopol 934 and HPMC K-100 in various ratios of gel and emulsion. DSC and IR spectral studies were performed to confirm the compatibility of drug and polymers in the formulations. The prepared Emulgel was evaluated for their physical appearance, pH evaluation, spreadability, rheological study, and drug content and invitro permeation studies. All formulation was evaluated for their release patterns. The result indicates that Emulgels offers better release, controlled release, or a stable atmosphere for the incorporated drug (Fluticasone Propionate). From studies we can conclude that topical application would be effective by applying through novel delivery system like Emulgel of Fluticasone Propionate.

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Author(s): Rajesh Asija Nitin Nama Deepak Sharma

Keywords

Topical delivery, Achieving, Twofold release, Incorporated., topical drug delivery

 
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