alexa Abstract | Development and evaluation of oral controlled release chlorpheniramine-ion exchange resinate suspension

Indian Journal of Pharmaceutical Sciences
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Abstract

An oral controlled release suspension of chlorpheniramine maleate was prepared using ion-exchange resin technology. A strong cation exchange resin Indion 244 was utilized for the sorption of the drug and the drug resinates was evaluated for various physical and chemical parameters. The drug-resinate complex was microencapsulated with a polymer Eudragit RS 100 to further retard the release characteristics. Both the drug-resinate complex and microencapsulated drug resinate were suspended in a palatable aqueous suspension base and were evaluated for controlled release characteristic. Stability study indicated that elevated temperature did not alter the sustained release nature of the dosage form indicating that polymer membrane surrounding the core material remained intact throughout the storage period.

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Author(s): AU Kadam DM Sakarkar PS Kawtikwar

Keywords

Controlled release, chlorpheniramine maleate, ion-exchange resin, formulation, Indion 244, suspending agent

 
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